Medicines that inhibit CYP2D6 activity, such as paroxetine and quinidine, may perhaps induce diminished clearance of oxycodone which may lead to a rise in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by eleven%, AUC by 13%, and t½ elim.Hyperalgesia Hyperalgesia could be diagnosed if t

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